hmmmm couple of things:
This layout:
Durations…is it really necessary to have 1500minutes durations on media item? (please adjust it a little bit)
Understanding Media Duration and how it affects the playback of a Layout
loop…you don’t really have to use it, but since you do, you might want to update your client to 1.7.6 there was a bug regarding this setting in earlier versions.
Schedule…this layout is set as a default layout for your displays, there is no need to schedule anything in this case.
Default layout will be always displayed.
Resolution…you monitor seems to be 4:3, definitely not 16:9, so you might want to consider changing the layout resolution to 4:3 as well (layout designer -> options -> background)
So when you adjust the durations and clear the schedule, give your player a moment to connect to the CMS and update the schedule/layout. Perhaps also restart it after that, it should be fine.