Could you tell us if you’re using Docker or manual/custom installation on web server please?
If it’s not docker do you have
/web in your CMS address?
As for layouts, please see - Why won't my layout play? / The splash screen plays instead of my layout
It could be also good to make sure your CMS/server has correct timezone settings.
If you’d show us a screenshot of status window on your player when the issue occurs that should clear some thing as well (press ‘i’ on your keyboard while Xibo for Windows has focus).
If you’re unsure if your layout is valid, I’m happy to take a quick look at it, you can export your layout and send it to me private message (you will most likely need to upload it somewhere and share the download link with me).