I have similar experience, we’re using MSD300 sending card, MRV330 receiver card, and QiangLi led module to display 1024x384 led screen.
We have replaced NovaStudio with Xibo player and NovaPluto with Xibo CMS.
The player computers are Intel NUCs and Android TV Boxes (eg. Minix Neo X7).
The setup for configuring the led display went ususal as described by NovaLCT-Mars.
To use Xibo first set the resolution of sending card to the resolution supported by both the player computer and the sending card, for example 1080x720, then create new layout with that resolution, then create regions (and media in them) inside 1080x720 layout but not exceeding 1024x384 screen size (eg, can’t have 400x600 region without being truncated).