1.8.1 client error just blank screen

Your layout does have an empty region. Eagle-eyed @Peter spotted it.

Region ID 18 in your paste:

<region id="18" width="9600.0000" height="1080.0000" top="0.0000" left="0.0000"><options/></region> 

You’ll need to remove that for the layout to be valid. It’s full screen, and first, so likely under your other regions.