Thank you.
So:
Embedded module in Xibo:
<iframe width="1920" height="1080" src="https://www.youtube.com/embed/y60wDzZt8yg?autoplay=1" frameborder="0" allowfullscreen></iframe>
Web page module in Xibo:
URL: https://www.youtube.com/embed/y60wDzZt8yg?autoplay=1
Both are working for me (for more than 15min now.
What duration did you set for this item? Do you have anything else in the same region?
Also please make sure that you have IE11 installed and the right setting in registry regarding browser emulation with xibo player, details: Enabling HTML5 in the Windows .net Player