Hi,
I would suggest the very same thing as @cslaughter did, update CMS/players to the newest versions.
Other than that you might want to have a look at our FAQ sections especially those 3 topics are probably related to your problem.
Why won't my layout play? / The splash screen plays instead of my layout
Using Tickers, Forecast, Twitter and other external resources that make use of HTTPS connections
Enabling HTML5 in the Windows .net Player